Modular Effector Mechanisms Can Reach Across Innate and Adaptive Immune Systems

Elstar’s UniTI platform brings true mix-and-match, plug and play simplicity to the engineering of complex, multi-functional molecules with four or more functional domains. Bi-functional, tri-functional, and tetra-functional formats can all be seamlessly achieved in a stable molecule with attractive IgG-like structural and pharmacological features.

By employing different effector domains, our molecules are able to modulate multiple immunological mechanisms controlling both the adaptive and the innate immune mechanisms.  A broad array of antibody-based binding components can be combined with a choice of binding domains, cytokines, receptor traps, enzymes, functional ligands, or any other bioactive proteins.

Elstar’s Approach Rapidly Generates Complex Multi-functional Molecules

Elstar protein engineering molecule showing how the various arms of the molecule can have different therapeutics attached to two arms

Bi-functional

Elstar protein engineering molecule showing how the various arms of the molecule can have different therapeutics attached to three arms

Tri-functional

Elstar protein engineering molecule showing how the various arms of the molecule can have different therapeutics attached to all four arms

Tetra-functional